Curr Biol：分散注意力可适当缓解疼痛感

近日，刊登在国际著名杂志Cell的子刊Current Biology上的一篇研究者报告指成，利用心理干扰（分心）的方法可以使得头痛降低，然而这种头痛缓解降低的效应相当表现在头部。这项研究者推断出是基于适用高分辨率的骨髓；也磁共振激光高效率（fMRI高效率），对人们由于高温引起的头痛水平透过研究者，研究者揭示，心理干扰显然可以在的中央头痛处理早期抑制头痛频谱的传入。来自汉堡-埃彭多夫大学学院的学者Christian Sprenger声称，这种现象相当仅仅是一种心理现象，而是一种活跃的神经机制，可以降较低从神经纤维上升至大脑高级周边的头痛频谱。

这种效应涉及到了诱导的类物质，这种物质产生自大脑，在降低头痛的过程中扮演着最重要角色。研究者其他部门让行动者分别完成一个单纯或者一个极难的记忆性勤务，必须他们想到信件的文字素材，同时给行动者肩膀上施以高温。透过极难勤务的行动者更加心烦意乱时，他们不会不已比较大的头痛，通过fMRI高效率反映成这些行动者的神经纤维周边活性更加比较较低，fMRI通常是用来校准大脑活性的改变。

Sprenger和他的威尔森然后重复了科学实验，这次他们给予行动者一种药物-钠洛酮（抗休克的令人满意药物，可以阻挡阿司匹林的效应）或者一般而言的盐水流经，结果显示，相较只流经一般而言盐水的行动者，适用阿司匹林拮抗剂的行动者由于视线分散，引起的头痛缓解降较低了40%，因此表明诱导的扮演着最重要作用。

学者的推断出揭示了心理过程可以深入地改变人们的头痛经历，并且对于诊疗也有极其最重要的意义。学者声称，我们的研究者推断出给头痛疾病化疗提供了认知行为化疗的方法。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.